The "Indians" have pretty much assimilated into the patchwork fabric that is the US. Many nations are the product of immigration, migration, invasions, etc... and the idea of "pure" blood isnt a real big thing here. I've got a little Cherokee heritage mixed with British / Irish/ Welsh/ Swedish, but the last one of my ancestors to hit the shores got here almost 200 years ago. The governor of New Mexico has both Indian and Mexican roots... quite a few of us have some native American heritage if we dig back a bit. Our incoming president is half white / half black. Basically the place is a melting pot. Not a big deal. People are more interested in what you can do than where your great-grandfather came from.
It is always amazing to me how many places don't have the level of cultural diversity the US has. It is a normal thing for me to see all sorts of different people walking the streets from all sorts of cultural backgrounds but we all treat each other respectfully and we are all Americans. I live in Kentucky which is stereotypically a backwater state full of barefoot hillbillies and my little town has Muslim doctors, Hindu school teachers, white people, black, people, red people, nice people, mean people... We all go to the same grocery store, we all send our children to the same schools and watch the same high school sporting events. I know a lot of people with Native American blood and all kinds of other heritages and regardless what their politics are they all consider themselves US citizens and voluntarily.