which is the best placement

hello, which is give me the most CTR??

1. Ads 336x280 | Ads 336x280

2.
Ads 336x280
------------
Ads 336x280


Thanks a lot.

 

there's not a black and white answer to this. why not run each format for a week and compare results

 

As romance said, the only way to find out is to test how it will perform on your website.
There is no such thing as best performing ads. Different formats, different colors will perform differently on various websites. It depends on your layout, etc.

 

I would try placement #2 and place content on the right of these adsense blocks.