windows + e, to run windows explorer. windows + r, to run run command. I use it a lot to quicken my work. I also use undo (ctrl + z)
My space bar is all shiny because of where i practically wore off the paint or whatever that coats the keyboard.
F5 (to refresh the page in IE & to run executable in Visual C++) Ctrl+F7 (to compile code in Visual C++) Ctrl+F5 (to generate executable in Visual C++) Ctrl+F8 (to debug code in Visual C++) F9 (to insert breakpoint in the code in Visual C++) F10 (to move in lines in the code of Visual C++)