If you're only talking about Google search engine, who knows.. They're google. Haha, it's best to be prepared for anything and keep out our eyes open for everything
Your question is a bit unclear, but if you just generally want to know what SEO methods are likely to give the best results in the coming year, I personally am putting a lot of weight in On Page SEO. Google has been moving value from Off Page SEO, and it looks they will continue to do so, meaning that we have to be more vigilant in the backlinking we do to ensure quality. On the site, quality content. Off the site, high relevancy with links. Those are looking like main focus areas for 2012.