USB flash drives are involved in a large number of incidents of data breach. How do you make your USB drive safe?
Don't be an idiot and leave it in a taxi, on a train, etc. Actually, in the UK government it's supposed to be mandatory that laptops, USB drives, etc, are all encrypted. However, it's the idiots at the top who get exemptions (and lose them). It should apply to everyone, IMO. It would be good to see encryption as a standard part (i.e. built into the hardware and supported at driver level) of all removable media. Optional, though, as I know it's not for everyone. Anyway, it's not the devices to blame, but the idiots. So, the solution is either to fire these idiots or train them properly in data security (not just how to do it, but so they understand respect for data). I think some of them won't learn until they are directly scammed, though. Maybe not even then.
Besides what is mentioned above, I would refrain myself from inserting USB drives into untrusted machines for example the public computers.
And 2 tutorials http://www.howtogeek.com/61810/how-to-protect-your-flash-drive-data-with-truecrypt/ http://www.utwente.nl/icts/en/handleidingen/overig/truecrypt_xp-en_m_en.doc/ Code (markup):