I use Adobe Photoshop and flash, and they are enough for the completion of my work. So i never go for any other tool. For website designing i also use Microsoft frontage.
I use below tools for effective Graphic And Web design 1. Adobe Photoshop 2. Basecamp 3. Font Doctor 4. BrowserShots 5. Blender 6. Adobe Kuler 7. Favicon Generator
CorelDraw, InDesign, Adobe Illustrator and Adobe Photoshop. My primary tool is CD and then comes PS and Illustrator.
I consider Illustrator to be the software I'm most comfortable with though I do have reasonable knowledge of photoshop too