Not Bad, but you can make it horizontal instead of vertical [i mean the two ad blocks], a long rectangle just below your two logos...
The squares don't really fit too well at the top. Try what bnts said and put a horizontal ad at the top and put the square ads somewhere else.
The vertical ad in the right down side > should be changed to horizontally and go under main contents in center i think the rest is nice also the space from top section to your log is way too much
Looks fine to me. I would add a horizontal link unit right below the featured downloads, above News & Updates.