But don't forget that you have to pay $49 just for signup at 2CO while paypal and Moneybookers both are free to join. Paypal widely used and Moneybookers where paypal not support. Both are good IMO. DON.
I wish more and more services accept Moneybookers or AlertPay. Paypal is like a monopoly right now and they are acting just like one .... if there's a good competitor to Paypal, their service (which is crap now) would improve ... But personally I had no problem till now either with MB or Paypal (except that Paypal's customer services seems to be a joke)
I must say i have also never had a problem with moneybrookers as customers can also pay via this option, but maybe the reason i have not had a problem is because no-one has ever payed through moneybrookers.
Moneybookers is a great service but there customer support service is usually a waste of time unless you call I would say go with alertpay as many are starting to use it.