Try entering one detailed targeting option in the Interest box instead of adding a bunch of them. This way, your results would probably determine which targeting option needs to be eliminated. Do this: Hover to the Duplicate option under your ad set and click on it. Make (for example) four copies of it. That’ll leave you with five ad sets. Open one of the four copies. Scroll down and remove your previous interests and add one targeting option, then change the ad set name accordingly. Do the same operation for the other three copies. Set a new name and interest for each one. With these five ad sets, your results are now broken into five pieces. In the long run, you'll get better results this way.