I was wondering can we purposely base the content on the site and have frequent keywords to target high paying keywords from adsense. I am talking about putting random content to effect the adsense ads. This would be obviously unrelated content to the actually site. Also I would use a domain and site title with these keywords. Getting the traffic to the site wont be a problem but do you think google will have a problem with this if I am trying to target something unrelated for the sole purpose of profit?
May I point you in the direction of the Adsense Program Policies. In particular: In my opinion your site would qualify as being MFA.
Well, the dutch version of the program policies (I can't see the English) says (in translation): "in some cases you can show ads on the same page where you have google ads. This is dependent on the kind of ad. Contextual ads can't be shown on the same page with google ads." And from the program guidelines: "you can't show ads designed to look like google-ads". So: some ads (like direct amazon-links) are fine, while others, like YPN aren't.