The answer is as below: string strTo = txtTo.Text; for (int i = 0; i < strTo.Split(',').Length;i++ ) { string strMailId = strTo.Split(','); try { MailMessage msg = new MailMessage(); msg.From = txtFrom; msg.To=txtTo; msg.Subject = txtSubject.Text; msg.IsBodyHtml = true; msg.Body = txtMail.Text; msg.Priority = MailPriority.High; System.Net.Mail.SmtpClient client = new System.Net.Mail.SmtpClient("smtp.gmail.com", 25); client.UseDefaultCredentials = false; client.Credentials = new System.Net.NetworkCredential("xxx@gmail.com", "xxx"); //Email and Password client.EnableSsl = true; client.Send(msg ); ScriptManager.RegisterStartupScript(btnSend, typeof(Page), "Confirm", "alert('Your enquiry sent successfully!');formReset();", true); } catch (Exception Ex) { ScriptManager.RegisterStartupScript(btnSend, typeof(Page), "Error:", "alert('Oops! Some error occoured.')", true); } } For more knowledge go through http://failuredeveloper.blogspot.com/ Thanks & Regfards