One tips here is to Optimize the Twitter account name to best reflect your brand. Your name is what appears next to your profile, which can be different than your handle/URL. You obviously want an account name that promotes yourself, your company or your brand. You should also consider which variation of you brand name has the most search frequency every month.
Try cloaking your twitter links with better urls too. Instead of bit.ly/afarer08 use something like you.com-vip.info .. You can get them free at http://www.brainyurl.com