Here is my opinion: 1. Follow a large number of people. 2. Wait for them to follow you back. 3. Post a new topic on your blog/website. 4. Tweet about it different times a day. 5. You'll get visitors on your site. 6. Follow new people again. 6. Repeat steps 1-5 again. Follow me on Twitter: http://twitter.com/MaheshKukreja
You must love Twitter in order to succeed and it's not hard. Follow about 50 people at first and comment what they tweet, try to make friends and they will be interested in your tweets too. Repeat the steps and you are done. If you're not active you won't attract any interest on you.