Well there are lots of tutorials that explain how to make responsive web design. If you are planing plain HTML/CSS/jQuery then go for 960 grid system. It is great for all screen sizes.
Here is, for example, nice tutorial http://www.onextrapixel.com/2011/09/12/create-a-responsive-web-design-template/ search in google. there are plenty of useful things there.
If you had to come to DP to ask, it's too far over your head to bother with, so just give up now and find something else to do.
Hey !! You must learn HTML/CSS/Jquery and some PHP, I'd suggest to learn how to use Google ! Good luck