Does customization of link code affect Search engines ??

Hi , I have a Question before all major SEO people . Do these two linking codes Make any difference to search engines??

1.

<a href="http://URL.com">Anchor</a>

Code (markup):

&

2.

<a href="http://www.URL.com" class="postlink"><span style="font-size: 150%; line-height: normal"><span style="color: #FF0000">Anchor</span></span></a>

Code (markup):

I am a bit confused over this please post your opinions on it ??

 

They should be the same, but the second could look invisible. And that would be a big difference

 

If it is visible there is hardly any difference

 

Put the style of span in your stylesheet list too.
Exemple:

.postlink {
font-size: 150%; line-height: normal; color: #F00;
}