Prioritywise, Facebook, Twitter, Digg, StubmbleUpon. But you can change your priority for different type of websites, however I suggest to stick to at least these ones, no matter what type of buisness you have.
I think the biggest has got to be Facebook. I see a lot of sites adopting Twitter though, I really must give that a try sometime!
Facebook is the social network. Start with a page there. It's the #1 in traffic, wide userbase and very professional fan pages offered. The tools they have is great. You can add some stumbleupon bookmarking for extra visitors, and twitter for followers. AND http://www.facebook.com/twitter/ your facebook pages can auto-post your updates to yourlinked twitter accounts, making these twitter accounts run on auto! Very practical. Use these and you're good for free traffic and recognition.
Facebook for numbers & community building/targeting, Twitter for indexing....and if you're into music like me then myspace is still a must for bands