What do you mean by best I feel Blueprint very handy for me. Visit this site for more information: http://www.blueprintcss.org/ Anyway, there are also other developed frameworks, you may try them out and pick your favorite one. YUI (The Yahoo! User Interface Library) http://developer.yahoo.com/yui/ YAML (Yet Another Multicolumn Layout) http://www.yaml.de/en/ Content with Style http://www.contentwithstyle.co.uk/content/a-css-framework Tripoli http://devkick.com/lab/tripoli/ Elements http://elements.projectdesigns.org/ WYMstyle http://www.wymstyle.org/en/ Taffy CSS Framework http://code.google.com/p/taffy-css-framework/