I'm doing a spot of web building today which has included changing various DNS entries and Nameservers. Now usually I use Chrome/ium exclusively but it seems that the usual "ctrl+F5" trick doesn't work in Chrome. You manually have to go and clear the cache from the menu. Muchos annoying!
Chrome documentation states that Ctrl+F5 or Shift+F5 should "Reloads your current page, ignoring cached content. Another interesting option is to open a new incognito window (ctrl+shift+n). This window won't use any stored cookies, cached content, or dns resolutions, so you can test stuff in it without slowing your normal browsing down by dumping the cache.