This site makes no money at all despite the fact it receives a fair bit of traffic. About 1500 new visitors on most days. Arsenal Maybe I need a new layout?
Let me give my opinion your layout is ok for now. Good that you have PR5 already. move adlink unit on top put large rectangural ads bottom (in each page) if it's possible put leader board on top of page, but that will make your top header pic not interested (but who cares since that header pic don't give your a cent) and might have adlink unit under your top header pic I guess the long sky crab on the right side will not make a good click try new thing every 4 - 5 days to see what can make higher CTR. i tried for myself for one of my website and now maintain at 3 - 4% CTR
but hell,, 1000 visitors per day could make more money than my website. my website is just about 300 - 600 per day. Yeah,, try to understand my English LOL also another thing,, personally I will not apply everything people suggest if that make my website look weird or messy. I would implement something with a good design too.
I'd try a single large square right before the first post. Try to make it look like a blog post the best you can. Good Example here: http://herwife.com/2006/04/synthetic-hormones.html
Consider moving your navigation menu to the left side and moving your posts to the left. If you don't want to add a leaderboard, trying blending a horizontal text link unit underneath your top graphic.