the most important thing of all is to generate a lot of traffic coz more traffic, more clicks, more money.
if you get good traffic then you can make money with adsense with "Good Niche and good placement of Ads"
high quality content, create a link exchange section, add about 10 related links to your website, always update and show new content so the user has a reason to come back. social bookmarking helps, and articles. if you have $ to invest, use google adwords , you invest but you get back . regards & good luck
1. Be patient, success with adsense is hard work and does not come over night 2. don't risk your adsense account by doing stupid things 3. Experiment, experiment, experiment 4. never stop optimizing your ads through experimenting 5. Track each of your Ads with its unique channel