We've joined with Art.com but I'm beginning to consider removing the association as its not really profitable. What do you guys believe are affiliations ever worth it?
Affiliations are definitely worth it when you align yourself with the right company. You need products that not only sell like crazy to a large market, but that will make repeat sales over the long haul. Perhaps art is a hard sell in these economic times?
Your best approach is to try different affiliate programs before you decide whether they are worth the hassle of not. Some will work well with you, some will not work, and some will work a little. The better they work depends on how much work you put into it and how long you do it for. But programs can be profitable.