I myself have played/GMd for over 15 years now, started with Vampire: the Masquerade. I've pretty much run through the gamut of D&D and its various iterations, oWod, GURPS, FATE... I have to say the most fun I've had was with a gonzo game of Forgotten Realms, starting with 3.0 and then updating it to 3.5. Druids are just made of so much win. =D What have you played, and what are your fondest memories from your games?