Thanks a lot. We all turned out to be great persons, she did a hell of a job considering she had to take care of all of us, so yes, i'm taking good care of her now.
I have seen how alcohol ruins relationships. One of my friend's father is alcoholic and how he suffered through his studying period and still what he faces I know very closely... Thats why its better to stay away from alcohol.
My father was an alcoholic and a pretty bad one My mother divorced him because of that, living with him was a nightmare and of course he died because of his stupid addiction... Because of all these I don't drink alcohol, I can't stand it
As of today im on a pill called Antabuse... basically with this pill... once consumed alcohol is a no no. It will make me vomit. One thing I like about this pill is that say one day I decide not to take it. That still wont make drinking easier as its in the system for around two weeks. So no cheating.
Seizure drug shows promise as potential therapy for alcoholism A new study conducted on mice has shown that a seizure drug, called gabapentin, could act as a potential therapy for alcoholism by reversing cellular effects. In the study, alcohol-dependent rodents receiving gabapentin drank less alcohol, and this led the scientists to say that gabapentin normalizes the action of certain brain cells altered by chronic alcohol abuse in an area of the brain known as the central amygdala, which plays an important role in fear- and stress-related behaviours, as well as in regulating alcohol drinking. "The results are exciting. Our research shows that gabapentin not only changes the alcohol-consumption patterns of addicted rats (and not of the control group), but also may reverse some of the effects of addiction on a specific neurotransmitter in the brain," said Scripps Research Assistant Professor Marisa Roberto, Ph.D., who was first author of the study. "This is an example of the strength of the translational approach of the Pearson Center, where the clinical uses of gabapentin led us to hypothesize that gabapentin may act to restore homeostatic dysregulation of the GABAergic system. Cellular and behavioral studies converged to suggest that indeed gabapentin could normalize GABAergic tone in a specific brain region known to be dysregulated in dependent animals. Such results provide a strong rationale for translating these observations back to the clinical setting for the treatment of alcoholism," said George Koob, Ph.D., a member of the research team. Earlier, gabapentin was shown to effectively treat alcohol withdrawal and reduce alcohol consumption and cravings following detoxification in alcoholics, but the mechanism was unclear. In the new study, researchers have detailed the action of gabapentin (known commercially as Neurontin)-a structural analogue of the inhibitory synaptic transmitter gamma aminobutyric acid (GABA)-on neural signalling in the brain. The scientists first tested the effects of gabapentin on the behaviour of alcohol-dependent and non-dependent rats and found that alcohol-dependent rats that received gabapentin drank significantly less alcohol and demonstrated less anxiety-like behaviour in the face of alcohol abstinence than those who did not receive the drug. However, the behaviour of non-dependent rats receiving gabapentin remained unaffected. The results were same when the rats received gabapentin systemically and when the medication was infused directly into the central amygdala region of the brain. At the cellular level, dependence on alcohol is linked to increased strength of inhibitory synapses (junctions between two nerve cells) in the central amygdala. And now the researchers have found that gabapentin, like alcohol, increased the strength of these central amygdala inhibitory synapse cells from non-dependent rats, but decreased their strength in cells from alcohol-dependent rats. However, in the presence of a specific inhibitor of so-called GABAB receptors, these effects of gabapentin disappeared, which suggested that gabapentin's cellular mechanisms likely involve changes in release of the transmitter GABA at the inhibitory synapses. Also, they found that the sensitivity of GABAB receptors decreased with alcohol dependence, suggesting a biological mechanism for the development of alcohol dependence in general and for gabapentin's contrasting effects before and after long-term alcohol exposure in particular. Now, the scientists are planning to further explore the mechanism of action of gabapentin in the brain.
the best decision you will ever make. I've seen a lot of lives destroyed entirely because of alcoholism...I'm happy for you.
Been over a week or so now... and not a single drop of alcohol.. or the feeling to want to drink alcohol.
Keep it up bro, I myself am heading to that road of staying sober. It does not help that im polish , Alcohol all around me. Ive been going out to bars for quite a while now, at the beginning I did it as a social thing but now its become just a weekend getaway from all the stress.
I'm usually pi$$ed when I'm on here ... though tonight I'm fine... the Vodka hasn't been touched... got no red-bull.