I have a site that has 35k uniques per day and 60k page views per day; my question is, if I place AdSense on the site would Google freak out or not? Does anyone have experience with this? Thanks!
As long as the content of the site meets adsense TOS you wont have any trouble at all subject to the niche and the geo you could well make some nice revenue.
Mega B is correct, as long as you aren't violating the TOS you're in the clear. I've noticed that adsense on high volume sites has lower conversion rates than laser-targeted niche sites, but money is money. Now, if you have a high volume niche site, all the better.
They would be more than happy to have you as a publisher as the the more you earn the more they earn. Just follow the rules..
Google likes big publisher and you have high traffic site then why they don't like you. What you should think is about your visitors. If your visitors are very targeted (direct visitors), you will earn less with Adsense since not many of them click on the ads. They need only information from your site (in this case you should find a good CPM). If your visitors are from Search Engine, then I am sure that you will make more money with google adsense. These are just my opinions only. You may think before act.