Hi. I have just redesigned my blog and decided to reshuffle my ad placement. Here's the link to my blog: http://conradmiguel.com/ Also, it is only on post pages where three text block units are maximized. ;D
the advert on the homepage seems abit "IN YOUR FACE" if you know what i mean. other than that i think its pretty well, you could mess around with the red url color in the ad, sometimes its better having it the same color as the text to make the title stand out.
Make the leaderboard adsense ad background and outline color the same as the background color of your webpage around the ad. This will allow your adsense ad to blend in better. Also, consider using a rectangle or square adsense ad instead, since these are shown to have high click through rates (CTR).