I got a pretty large list of keywords from keywordspy for dating. Being a Adwords newb I uploaded 1 of the files with 2000 keywords to adwords to get crackin. I paused the campaign for a few days until I had more time to work on it and then went thru the keywords and noticed alot of the keywords were inappropriate and some down right gross. I deleted the ad group and filtered thru the keywords reducing the list to only appropriate keywords in groups of 50-100. Will adwords take offense to this? Sorry if I sound paranoid, but I know how picky Google is with adsense. I don't want to get banned or anything for something so stupid.
I've never been a fan of using automatically generated keyword lists. They're useful for suggesting a few keywords that you may not have thought of, but that's about it. It's a pain in the asre, but I've found the best way to create keyword lists is by hand (though Excel's handy for adding adjectives like Quick, Cheap or Easy to my keywords...)
That works for small to medium campaigns, but try making up/scraping 75,000 keywords and going thru each one.
I'd recommend to use the keyword tool that adwords provide. It's what I use to get keywords that I know won't get me in trouble.
I'd do it section at a time. If the alternative is bidding on a lot of keywords that aren't very relevant, then it's worth it. Do you really have 75,000 completely different keywords that accurately describe what you do/sell? The only times that I've had a long keyword like this, it's due to 1) An extensive product list (in which case the keyword suggestions won't help) or 2) The same, relatively small number of basic keywords with a lot of different adjectives or qualifiers (in which case you can build the complete list quickly in Excel or something similar)
This is for dating so pretty much anything dating related counts as a keyword. I'm experimenting, lots of people I know just throw in a ton of keywords into a campaign and see how it goes then tweak it as they go along instead of spend hours setting up perfectly targeted ad groups.
If you dump a ton of keywords into a campaign, I'm positive that adwords has an "uh-oh, this guy didn't read the help center" flag that automatically gives your account a low quality score. Even for dating 75,000 is nuts. Go lean and mean to start, testing, pausing and adding new ones slowly has always produced the best campaigns on adwords.
I wouldn't quite go that far , but it's certainly going to make it nigh-on impossible to optimise your campaign effectively (and Google will be setting your Quality Scores based on very little data, so your minimum bids could be all over the place).