I'm starting another website and I want to be more aggressive with the advertising campaign (well, because it's costing me a fortune). I'm looking to do something like every 5th post read, there is a banner ad that pops up across the entire screen, silhouetting it to black. On my current website, I have Google Adsense, but I want to try other avenues.
What you suggest sounds like a good idea. You should restrict it to not display to the user such advertisements more than 2 or 3 times per day and you would see how it affects your site.
Yes, being too aggressive will drive traffic away. I'd be careful if this is a new site trying to build a following.
To be aggressive you will need a top notch web production. Create small, more targeted web pages with content that emphasizes only on a few keywords.