I found this on technorati, and it really did make a difference. The most dramatic improvment is when I disabled the indexing services. http://computerwhiz1960.spaces.live.com/Blog/cns!7BB2745408D4C6D3!188.entry
Some nice tips there in the article. And here is my tip. Buy more RAM. If you use your computer more than 2 hours a day then the extra RAM is worth the investment.
you mean tweaking it? I love how my 3 month old laptop is 32.88% slower now than it was the day I got it....I know I've installed some SW but come on